Menu
CTX1B is a cyclic polyether compound with a rigid structure, consisting of 13 rings fused by ether bonds. It is a secondary metabolite derived from biotransformation processes undergone by algal ciguatoxins produced by the microalgae Gambierdiscus spp. CTX1B is primarily found in the tissues of carnivorous marine invertebrates and fish from the Pacific region [1,2,3].
208 831 XPF – 417 662 XPF
| Product identification | CTX1B |
|---|---|
| Name | Pacific Ciguatoxin CTX1B |
| Formula | C60H86O19 |
| Description | CTX1B is a cyclic polyether compound with a rigid structure, consisting of 13 rings fused by ether bonds. It is a secondary metabolite derived from biotransformation processes undergone by algal ciguatoxins produced by the microalgae Gambierdiscus spp. CTX1B is primarily found in the tissues of marine invertebrates and carnivorous fish from the Pacific region [1,2,3]. |
| Category | Natural product -Poison |
| Target and biological activity | Ciguatoxins (CTXs) are potent marine neurotoxins that act as activators of voltage-gated sodium channels (VGSCs) [4]. They bind at site 5 of the alpha subunit of VGSCs resulting in the opening of the Na+ channels, and firing of repetitive action potentials. |
| Packaging | Price(€) |
|---|---|
| 0.5 µg | 1 750.00 € |
| 1.0 µg | 3 500.00 € |
CTX1B is sent in powdered form
| Name | Pacific Ciguatoxin CTX1B |
| CAS number | 11050-21-8 |
| PubChem | 5311333 |
| Toxicity | Lethal dose 50% (DL50) = 0.25 – 0.36 µg/Kg (i.p. on mice) [3] |
| Chemical name | CTX1B |
| Molecular weight | 1110.6 g/mol [3] |
| Physical form | powder |
| Solubility | CTX1B is a liposoluble neurotoxin |
| Storage | Ciguatoxins are usually stable molecules. It is recommended to store CTX1B at -20°C in its original container, not opened, until used |
| Hygiene and security | Wearing gloves, safety glasses and goggles is recommended |
[1] Legrand A.M., Litaudon M., Genthon J.N., Bagnis R., Yasumoto T. (1989). Isolation and some properties of ciguatoxin. Journal of applied phycology, 1(2) 183-188. https://doi.org/10.1007/BF00003882
[2] Mak Y. L., Wai T.-C.; Murphy M. B., Chan W. H., Wu J. J., Lam J. C. W., Chan L. L., Lam P. K. S. (2013). Pacific ciguatoxins in food web components of coral reef systems in the Republic of Kiribati. Environ. Sci. Technol. 2013,14070-14079. https://doi.org/10.1021/es403175d
[3]Food and Agriculture Organization of the United Nations & World Health Organization. (2020). Report of the expert meeting on ciguatera poisoning: Rome, 19-23 November 2018. World Health Organization. https://apps.who.int/iris/handle/10665/332640
[4] Lombet A., Bidard J.N., Lazdunski M. (1987). Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage‐dependent Na+ channel. FEBS letters, 219(2), 355-359. https://doi.org/10.1016/0014-5793(87)80252-1
Material Safety Data Sheet available on demand. Contact us.
