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CTX4A is a cyclic polyether compound with a rigid structure, consisting of 13 rings fused by ether bonds. It is a secondary metabolite synthetized by microalgae in the genera Gambierdiscus and Fukuyoa[1,2] . CTX4A is also found in the tissues of marine invertebrates and fish from the Pacific region [1,3].
167 065 XPF – 334 130 XPF
| Product identification | CTX4A |
|---|---|
| Name | Pacific Ciguatoxin CTX4A |
| Formula | C60H84O16 |
| Description | CTX4A is a cyclic polyether compound with a rigid structure, consisting of 13 rings fused by ether bonds. It is a secondary metabolite synthetized by microalgae in the genera Gambierdiscus and Fukuyoa [1,2]. CTX4A is also found in the tissues of marine invertebrates and fish from the Pacific region [1,3]. |
| Category | Natural product – Poison |
| Target and biological activity | Ciguatoxins (CTXs) are potent marine neurotoxins that act as activators of voltage-gated sodium channels (VGSCs) [4]. They bind at site 5 of the alpha subunit of VGSCs resulting in the opening of the Na+ channels, and firing of repetitive action potentials. |
| Packaging | Price(€) |
|---|---|
| 0.5 µg | 1 400.00 € |
| 1.0 µg | 2 800.00 € |
CTX4A is sent in suspension.
| Name | Pacific Ciguatoxin CTX4A |
| CAS number | 66231-73-0 |
| PubChem | 6437372 |
| Toxicity | Lethal dose 50% (DL50) = 1.4 – 2 µg/Kg (i.p. on mice) [3] |
| Chemical name | CTX4A |
| Molecular weight | 1060.6 g/mol [3] |
| Physical form | suspension |
| Solubility | CTX4A is a liposoluble neurotoxin |
| Storage | Ciguatoxins are usually stable molecules. It is recommended to store CTX4A at -20°C in its original container, not opened, until used |
| Hygiene and security | Wearing gloves, safety glasses and goggles is recommended |
[1] Satake M., Ishibashi Y., Legrand A.M., Yasumoto T. (1996). Isolation and structure of ciguatoxin-4A, a new ciguatoxin precursor, from cultures of dinoflagellate Gambierdiscus toxicus and parrotfish Scarus gibbus. Bioscience, biotechnology, and biochemistry, 60(12), 2103-2105. https://doi.org/10.1271/bbb.60.2103
[2] Chinain M., Darius T., Ung A., Cruchet P., Wang Z., Ponton D., Laurent, D., Pauillac S. (2010). Growth and toxin production in the ciguatera-causing dinoflagellate Gambierdiscus polynesiensis (Dinophyceae) in culture. Toxicon 56, 739-750. https://doi.org/10.1016/j.toxicon.2009.06.013
[3] Food and Agriculture Organization of the United Nations & World Health Organization. (2020). Report of the expert meeting on ciguatera poisoning: Rome, 19-23 November 2018. World Health Organization. https://apps.who.int/iris/handle/10665/332640
[4] Lombet A., Bidard J.N., Lazdunski, M. (1987). Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage‐dependent Na+ channel. FEBS letters, 219(2), 355-359. https://doi.org/10.1016/0014-5793(87)80252-1
Material Safety Data Sheet available on demand. Contact us.
