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P-CTX1B

Origin : Gymnothorax javanicus liver tissue

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CTX1B is a cyclic polyether compound with a rigid structure, consisting of 13 rings fused by ether bonds. It is a secondary metabolite derived from biotransformation processes undergone by algal ciguatoxins produced by the microalgae Gambierdiscus spp. CTX1B is primarily found in the tissues of marine invertebrates and carnivorous fish from the Pacific region [1,2,3].

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GENERAL INFORMATION

Product identification CTX1B
Name Pacific Ciguatoxin CTX1B
Formula C60H86O19
Description CTX1B is a cyclic polyether compound with a rigid structure, consisting of 13 rings fused by ether bonds. It is a secondary metabolite derived from biotransformation processes undergone by algal ciguatoxins produced by the microalgae Gambierdiscus spp. CTX1B is primarily found in the tissues of marine invertebrates and carnivorous fish from the Pacific region [1,2,3].
Category  Natural product -Poison
Target and biological activity Ciguatoxins (CTXs) are potent marine neurotoxins that act on voltage-gated sodium channels (VGSCs). Ciguatoxins bind at site 5 on the alpha subunit of VGSCs resulting in the opening of the channels at resting membrane potential. Ciguatoxins are VGSC activators [4].

PACKAGING AND PRICE

Quantity Price(€)
0.5 µg 1 750.00 €
1.0 µg 3 500.00 €

CTX1B is sent in powdered form

PHYSICAL AND CHEMICAL CHARACTERISTICS

Nom  Pacific Ciguatoxin CTX1B
NAS number 11050-21-8
PubChem 5311333
Toxicity Lethal dose 50% (DL50)=0.25-0.36 μg/Kg (i.p. on mouse) [3]
Chemical name CTX1B
Molecular weight 1110.6 g/mol [3]
Physical form Powder
Solubility CTX1B is a liposoluble compound.
Storage Ciguatoxins are usually stable molecules. It is recommended to store CTX1B at -20°C in its original container, not opened, until used.
Hygiene and security Wearing gloves, safety glasses or goggles is recommended.

REFERENCES

[1] Legrand A.M., Litaudon M., Genthon J.N., Bagnis R., Yasumoto T. (1989). Isolation and some properties of ciguatoxin. Journal of applied phycology, 1(2) 183-188. https://doi.org/10.1007/BF00003882

[2] Mak Y. L., Wai T.-C.; Murphy M. B., Chan W. H., Wu J. J., Lam J. C. W., Chan L. L., Lam P. K. S. (2013). Pacific ciguatoxins in food web components of coral reef systems in the Republic of Kiribati. Environ. Sci. Technol. 2013,14070-14079. https://doi.org/10.1021/es403175d

[3]Food and Agriculture Organization of the United Nations & World Health Organization. (‎2020)‎. Report of the expert meeting on ciguatera poisoning: Rome, 19-23 November 2018. World Health Organization. https://apps.who.int/iris/handle/10665/332640

[4] Lombet A., Bidard J.N., Lazdunski M. (1987). Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage‐dependent Na+ channel. FEBS letters, 219(2), 355-359. https://doi.org/10.1016/0014-5793(87)80252-1

Material Safety Data Sheet available on demand. Contact us.