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P-CTX4A

Origin : Gambierdiscus polynesiensis in vitro cultures

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CTX4A is a cyclic polyether compound with a rigid structure, consisting of 13 rings fused by ether bonds. It is a secondary metabolite synthetized by microalgae in the genera Gambierdiscus and Fukuyoa [1,2] . CTX4A is also found in the tissues of marine invertebrates and fish from the Pacific region [1,3].

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GENERAL INFORMATION

Product identification CTX4A
Name Pacific Ciguatoxin CTX4A
Formula C60H82O16
Description CTX4A is a cyclic polyether compound with a rigid structure, consisting of 13 rings fused by ether bonds. It is a secondary metabolite synthetized by microalgae in the genera Gambierdiscus and Fukuyoa [1,2]. CTX4A is also found in the tissues of marine invertebrates and fish from the Pacific region [1,3].
Category  Natural product – Poison
Target and biological activity Ciguatoxins (CTXs) are potent marine neurotoxins that act on voltage-gated sodium channels (VGSCs). Ciguatoxins bind at site 5 on the alpha subunit of VGSCs resulting in the opening of the channels at resting membrane potential. Ciguatoxins are VGSC activators [4].

PACKAGING AND PRICE

Quantity Price(€)
0.5 µg 1 400.00 €
1.0 µg 2 800.00 €

CTX4A is sent in suspension.

PHYSICAL AND CHEMICAL CHARACTERISTICS

Name  Pacific Ciguatoxin CTX4A
CAS number 66231-73-0
PubChem 6437372
Toxicity Lethal dose 50% (DL50)=1.4-2 μg/Kg (i.p. on mouse) [3]
Chemical name CTX4A
Molecular weight 1060.6 g/mol [3]
Physical form Powder
Solubility CTX4A is a liposoluble compound.
Storage Ciguatoxins are usually stable molecules. It is recommended to store CTX4A at -20°C in its original container, not opened, until used.

 
Hygiene and security Wearing gloves, safety glasses or goggles is recommended.

REFERENCES

[1] Satake M., Ishibashi Y., Legrand A.M., Yasumoto T. (1996). Isolation and structure of ciguatoxin-4A, a new ciguatoxin precursor, from cultures of dinoflagellate Gambierdiscus toxicus and parrotfish Scarus gibbus. Bioscience, biotechnology, and biochemistry, 60(12), 2103-2105. https://doi.org/10.1271/bbb.60.2103

[2] Chinain M., Darius T., Ung A., Cruchet P., Wang Z., Ponton D., Laurent, D., Pauillac S. (2010). Growth and toxin production in the ciguatera-causing dinoflagellate Gambierdiscus polynesiensis (Dinophyceae) in culture. Toxicon 56, 739-750. https://doi.org/10.1016/j.toxicon.2009.06.013

[3] Food and Agriculture Organization of the United Nations & World Health Organization. (‎2020)‎. Report of the expert meeting on ciguatera poisoning: Rome, 19-23 November 2018. World Health Organization. https://apps.who.int/iris/handle/10665/332640

[4] Lombet A., Bidard J.N., Lazdunski, M. (1987). Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage‐dependent Na+ channel. FEBS letters, 219(2), 355-359. https://doi.org/10.1016/0014-5793(87)80252-1

Material Safety Data Sheet available on demand. Contact us.